Preclinical evaluation reveals altered signaling networks and drug sensitivity in tumors handled under physioxia, suggesting standard ambient air alters cancer cell behavior.
compared to ambient air display distinct differences in key signaling networks including LGR5/WNT, YAP, and NRF2/KEAP1, nuclear reactive oxygen species, alternative splicing, and sensitivity to targeted therapies. Therefore, evaluating cancer cells under physioxia could more closely recapitulate their physiopathologic status in the in vivo microenvironment.
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Kumar et al. (2022) studied this question.
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