Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Daniel R. Goldberg; Ming‐Hong Hao; Kevin Qian; Alan Swinamer; Donghong A. Gao; Zhaoming Xiong; Chris Sarko; Angela Berry; John Lord; Ronald L. Magolda; Tazmeen N. Fadra; Rachel Kroe‐Barrett; Alison Kukulka; Jeffrey B. Madwed; Leslie Martin; Christopher Pargellis; Donna Skow; Jinhua J. Song; Zhulin Tan; Carol Torcellini; Clare Zimmitti; Nathan K. Yee; Neil Moss

doi:10.1021/jm070415w

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

Integration of computational methods, X-ray crystallography, and structure-activity relationships will be disclosed, which lead to a new class of p38 inhibitors that bind to p38 MAP kinase in a Phe out conformation.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Goldberg et al. (2007) studied this question.

synapsesocial.com/papers/6a9deb75c448d60cdc367d07 https://doi.org/10.1021/jm070415w

View Full Paper

Ask AI

Bookmark

Share

Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Ask about this paper

Abstract

Discussion

Cite This Study

Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading