Heterotransplantation of Human Glioblastoma Multiforme and Meningioma to Nude Mice

A human glioblastoma multi-forme (Br7) and a meningioma have been successfully xenografted sc in nude mice. Both were successfully passed to a second generation. Complete retention of the unique histologic features was noted in each tumor xenograft. Actively growing cultures from the glioblastoma xenograft have been established; they are composed of the cell types characteristic of glioblastoma. Immature and mature C-type particles, presumably representing a xenotropic mouse virus, are present in both grafts. The growth of these two tumors in nude mice may provide a useful model for etiologic, immunologic, and chemotherapeutic studies. An attempt to produce glioblastoma in nude mice by the injection of cells cultured from human glioblastoma T98 was unsuccessful.