Key result
Adipose tissue endothelial cells exhibit significant transcriptomic and functional heterogeneity, playing crucial roles in lipid metabolism, angiogenesis, and intercellular communication that are altered in obesity.
Why the study?
Endothelial cells significantly affect health and disease, and because adipose tissue is vital to cardiovascular health, understanding adipose endothelial cell biology and heterogeneity is important.
Adipose endothelial cells display significant transcriptomic and functional heterogeneity, playing a crucial role in lipid metabolism and intercellular communication that becomes dysregulated in obesity.
Highlights endothelial heterogeneity as obesity target; leaves open clinical translation pending interventional validation.
Cardiovascular disease is the leading cause of death globally. Endothelial cells (ECs), the key units of all vascular segments, have a significant impact on the health and disease of organisms. Adipose tissue is vital to cardiovascular health, therefore, understanding adipose EC (AdEC) biology is important. Recent data have highlighted the presence of distinct AdEC subpopulations that govern adipose tissue homeostasis. In addition to their role in nutrient metabolism and transport, AdECs are involved in bidirectional cellular communication with adipocytes, among other cells. These interactions are mainly mediated by paracrine factors, including noncoding RNAs. In this review, we highlight recent results showcasing the functions of AdECs in adipose tissue biology, metabolic homeostasis, and changes occurring in obesity.
No takes yet. Share an insight, caveat, or question.
Festa et al. (2023) conducted a review in Obesity and metabolic diseases. Adipose tissue endothelial cells (AdECs) was evaluated. Adipose tissue endothelial cells exhibit significant transcriptomic and functional heterogeneity, playing crucial roles in lipid metabolism, angiogenesis, and intercellular communication that are altered in obesity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: