The reciprocal translocation t(9;22) (q34;q11) that generates the Philadelphia (Ph) chromosome is present in most chronic myeloid leukemia (CML) patients. However, in 5% to 10% of newly diagnosed patients, a cytogenetic variant is observed.[1][1] In this issue of Blood , Marzocchi et al (on behalf
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François Guilhot (2011) studied this question.
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