Key result
The COVID-19 pandemic was associated with a significant increase in the prevalence of takotsubo syndrome, rising from 109.07 to 131.19 per 100,000 admissions compared to the pre-pandemic period.
Why the study?
The study explored the impact of the COVID-19 pandemic on the prevalence and outcomes of takotsubo syndrome by comparing trends before and during the pandemic.
Does the COVID-19 pandemic and concurrent COVID-19 infection impact the prevalence and in-hospital mortality of takotsubo syndrome?
Observational (n=137,015,481)
Yes
Does the COVID-19 pandemic and concurrent COVID-19 infection impact the prevalence and in-hospital mortality of takotsubo syndrome?
The COVID-19 pandemic was associated with a significant increase in the prevalence and in-hospital mortality of takotsubo syndrome, particularly among those with concurrent COVID-19 infection.
Increased vigilance for takotsubo warranted amid future stressors; leaves open whether COVID-19 directly drives excess mortality versus broader factors.
Background We explored the impact of the COVID-19 pandemic on the prevalence and outcomes of takotsubo syndrome (takotsubo) using the National Inpatient Sample (NIS) to compare trends before and during the pandemic. Methods This retrospective study examined data from over 137 million admissions during 2017-2018 (pre-pandemic) and 2020-2021 (pandemic). Results Our analysis revealed a marked increase in takotsubo prevalence, from 109.07 to 131.19 per 100,000 admissions over each two-year period. The majority of patients were elderly females, with a notable rise in associated comorbidities such as hypertension and diabetes during the pandemic. Mortality among takotsubo patients rose significantly, with an adjusted odds ratio of 1.28. Patients with concurrent COVID-19 infection had a mortality rate of 23.02%, significantly higher than 7.61% for those without. The length of hospital stays also increased, particularly among COVID-19 patients. Interestingly, the odds of developing takotsubo were lower in COVID-19 patients than in non-infected individuals, suggesting a broader pandemic-related stress impact. Conclusion Our findings highlight a complex interaction between viral infections, stress, and cardiovascular health, underscoring the need for integrated care strategies during global health crises.
No takes yet. Share an insight, caveat, or question.
Tran et al. (2024) conducted an observational in Takotsubo syndrome (n=137,015,481). COVID-19 pandemic period (2020-2021) vs. Pre-pandemic period (2017-2018) was evaluated on Prevalence of takotsubo syndrome per 100,000 admissions (p=<0.001). The COVID-19 pandemic was associated with a significant increase in the prevalence of takotsubo syndrome, rising from 109.07 to 131.19 per 100,000 admissions compared to the pre-pandemic period.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: