Key result
A ketamine, midazolam, and vecuronium infusion with 100% oxygen successfully maintained tissue oxygenation and cardiovascular stability in a patient with Down's syndrome and congenital heart disease.
Why the study?
Does a ketamine, midazolam, and vecuronium infusion maintain cardiovascular stability in a patient with Down's syndrome, VSD, and pulmonary hypertension?
Case Report (n=1)
No
Does a ketamine, midazolam, and vecuronium infusion maintain cardiovascular stability in a patient with Down's syndrome, VSD, and pulmonary hypertension?
A ketamine, midazolam, and vecuronium infusion provided stable total intravenous anesthesia in a patient with Down's syndrome, VSD, and pulmonary hypertension.
May support ketamine-based TIVA in Down syndrome with VSD and PH; leaves open generalizability beyond this single case.
A ketamine, midazolam and vecuronium infusion was used for total intravenous anesthesia in a patient with Down's syndrome, a ventricular septal defect and pulmonary hypertension. A mixture of ketamine 200 mg, midazolam 5 mg and vecuronium 12 mg in 50 ml of normal saline was infused at 0.5 ml/kg/hour. This simple technique and ventilation with 100% oxygen maintained tissue oxygenation and cardiovascular stability.
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Riley et al. (1991) conducted a case report in Down's syndrome, ventricular septal defect, and pulmonary hypertension (n=1). Ketamine, midazolam and vecuronium infusion was evaluated on Tissue oxygenation and cardiovascular stability. A ketamine, midazolam, and vecuronium infusion with 100% oxygen successfully maintained tissue oxygenation and cardiovascular stability in a patient with Down's syndrome and congenital heart disease.
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