Electrochemical Synthesis of 3,5‐Disubstituted‐1,2,4‐thiadiazoles through NH 4 I‐Mediated Dimerization of Thioamides

A electrochemical method for the synthesis of 3,5‐disubstituted‐1,2,4‐thiadiazoles through NH 4 I‐mediated dimerization of thioamides is reported. Using the inexpensive NH 4 I as electrolyte and catalyst, this electrosynthesis approach requires no oxidizing agents and enables the convenient production of diverse 1,2,4‐thiadiazoles products. The approach is an example of S−N bond construction through the electrochemical method. magnified image