Novel Bioactive Azaphilones from Fruit Bodies and Mycelial Cultures of the Ascomycete Bulgaria inquinans (Fr.)

Three new azaphilones, bulgarialactone A (1), B (2) and C (3), were isolated from both the mycelia and fruit bodies of the Ascomycete Bulgaria inquinans. Bulgarialactone A (1) and B (2) possess antimicrobial, cytotoxic and nematicidal activities, and inhibit the binding of 3H-SCH 23390 to the dopamine D1 receptor. The isolation, structure determination and biological activities of the bulgarialactones are reported.