Key result
Mucosal glucose absorption increased arterial NO concentration (from 353 to 540-550 nM) and caused arterial dilation, primarily generated by the arterial wall in response to venous-diffused materials.
Why the study?
Does mucosal glucose absorption increase perivascular NO concentration in rat intestinal vessels?
Population
9 paired small arteries and veins from 5 rats
Comparison
Mucosal absorption of 100 and 300 mg/dl glucose… vs Resting state, and 360 mosmol/l saline made…
Design
Preclinical
Authors
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Rat intestinal data suggest glucose-driven arterial NO release; leaves open translation to human postprandial perfusion.
Does mucosal glucose absorption increase perivascular NO concentration in rat intestinal vessels?
Increased arterial NO concentration during mucosal glucose absorption is primarily generated by the arterial wall in response to materials diffusing from venous blood, such as hypertonic sodium.
H. Glenn Bohlen (1998) studied this question. Mucosal absorption of glucose and hypertonic sodium superfusion vs. Resting state was evaluated on Perivascular NO concentration ([NO]) and arterial dilation. Mucosal glucose absorption increased arterial NO concentration (from 353 to 540-550 nM) and caused arterial dilation, primarily generated by the arterial wall in response to venous-diffused materials.
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