The exact role of genetic susceptibility and environmental factors in determining type 1 diabetes has not been clarified. The island of Sardinia has one of the highest rates of type 1 diabetes in the world (1). The contribution of genetic susceptibility to the etiology of type 1 diabetes has been investigated in several studies of migrants of Sardinian origin who live in various regions of Italy (2,3,4). However, few data are available on the risk of type 1 diabetes among immigrants of mainland origin who live in Sardinia (5). To further examine the contribution of genetic and environmental factors to type 1 diabetes in Sardinia, we enrolled all incident cases of type 1 diabetes diagnosed in the province of Oristano aged 0–29 years between 1993 and …
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Frongia et al. (2001) studied this question.
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