Phenelzine-Induced Fulminant Hepatic Failure

Letters1 April 1996Phenelzine-Induced Fulminant Hepatic FailureEsther Gomez-Gil, MD, Joan M. Salmeron, MD, and Antoni Mas, MDEsther Gomez-Gil, MDHospital Clinic Provincial; Barcelona, Spain, Joan M. Salmeron, MDHospital Clinic Provincial; Barcelona, Spain, and Antoni Mas, MDHospital Clinic Provincial; Barcelona, SpainAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-7-199604010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:During the last year, two of our patients who had received phenelzine (a monoamine oxidase inhibitor commonly used to treat depression and other psychiatric and nonpsychiatric disorders) for 4 months (22.5 mg and 60 mg twice daily, respectively) had emergency orthotopic liver transplantation because of fulminant hepatic failure [1]. Phenelzine-induced fulminant hepatic failure was diagnosed after adequate biochemical, serologic, immunologic, hematologic, and histologic studies were done to rule out other known causes of liver damage. These two patients fit the pattern previously reported for hydrazine derivative—induced hepatotoxic injury: delayed toxic effect, no evidence of hypersensitivity-mediated injury, and ...References1. Castells A, Salmeron JM, Navasa M, et al. Liver transplantation for acute liver failure: analysis of applicability. Gastroenterology. 1993; 105:532-8. Google Scholar2. Zimmerman HJ, Ishak KG. The hepatic injury of monoamine oxidase inhibitors. J Clin Psychopharmacol. 1987; 7:211-3. Google Scholar3. Zimmerman HJ, Maddrey WC. Toxic and drug-induced hepatitis. In: Schiff L, Schiff ER, eds. Diseases of the Liver. Philadelphia: JB Lippincott; 1993:707-83. Google Scholar4. Bonkovsky HL, Blauchette PL, Schned AR. Severe liver injury due to phenelzine with unique hepatocellular disposition of extracellular material. Am J Med. 1986; 80:689-92. Google Scholar5. Cook GC, Sherock S. Jaundice and its relation to therapeutic agents. Lancet. 1965; 1:175-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Clinic Provincial; Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byContributions to our understanding of fulminant hepatitis from the Liver ICU of Hospital Clínic Barcelona: Historical reviewAportaciones al conocimiento de la hepatitis fulminante realizadas por la Unidad de Cuidados Intensivos Hepática del Hospital Clínic de Barcelona: revisión históricaMining hidden knowledge for drug safety assessment: topic modeling of LiverTox as a case studyAn update on amine oxidase inhibitors: Multifaceted drugsHepatotoxicity of Psychotropic Drugs and Drugs of AbuseAdvances Pertaining to the Pharmacology and Interactions of Irreversible Nonselective Monoamine Oxidase InhibitorsLaboratory aspects of specific psychiatric disordersAntidepressant-lnduced Liver InjuryUse of psychotropics in special patient groupsMonoaminergic‐based Pharmacotherapy for DepressionThe Role of Monoamine Oxidase Inhibitors in Current Psychiatric PracticeAntidepressant-induced hepatotoxicityThe use of psychotropics in the medically illPhenelzine 1 April 1996Volume 124, Issue 7Page: 692-693KeywordsAcute liver failureAlcoholsDrugsHepatitisLiverLiver function testsMonoamine oxidase inhibitorsOrthotopic liver transplantationPhenotypes Issue Published: 1 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...