Chemical synthesis study demonstrates efficient diethylzinc-mediated radical addition to unactivated alkenes and alkynes, highlighting a chromatography-free route for fluorinated molecules.
Key Points
To develop a mild and efficient diethylzinc-mediated methodology for the radical 1,2-addition of perfluoroalkyl iodides across unactivated alkenes and alkynes.
Employed diethylzinc to initiate the generation of perfluoroalkyl radicals, including ethyl difluoroacetate radicals.
Conducted 1,2-addition reactions of perfluoroalkyl iodides across unactivated alkene and alkyne substrates under mild reaction conditions without chromatographic purification.
Achieved complete substrate conversion and high yields of fluorinated addition products with negligible byproduct formation.
Demonstrated excellent functional group tolerance across substrates while fully eliminating the need for column chromatography purification.