Natural antioxidants and synergists for tocopherol (Toc) have been isolated as acetone or ethyl acetate extracts from mycelial mats or culture broth of Eurotium species. The acetone extract, eluted stepwise with benzene and ethyl acetate by silica gel column chromatography, gave fractions that were synergistic with Toe. However, the benzene fraction appeared better because it was highly soluble in oil and did not change the color and taste of the oil. The metabolites in the benzene fraction differed in the various Eurotium species in their composition in respect to known metabolites with antioxidative activity.
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ISHIKAWA et al. (1985) studied this question.
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