Panhypopituitarism Following Hemorrhagic Fever with Renal Syndrome Due to Hantavirus

Introduction: Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease caused by viruses that belong to the genus Hantavirus.Hantaviruses produce a spectrum of illness characterized by fever, circulatory collapse, hemorrhages, and renal failure.Pituitary ischemia/infarction and necrosis are known causes of hypopituitarism, often remaining unrecognized because of subtle clinical manifestations.In this report, we present a case of a 60-year-old male patient who was referred to the emergency department (ED) for unexplained hypoglicemia, with panhypopituitarism following HFRS.Case Report: We, hereby, present a 60-year-old male patient admitted to the ED because of unexplained hypoglicemia, with panhypopituitarism following HFRS.Blood tests revealed panhypopituitarism and anti-hantavirus IgM and IgG positivity.Hormone replacement theraphy was initiated, and he was discharged for outpatient follow-up with total recovery. Conclusion:Panypopituitarism is an extremely rare complication of HFRS.Emergency medicine, internal medicine, and infectious diseases specialists should be aware of this complication to reduce mortality and morbidity.