The potential energy surface of an off-lattice model protein is characterized in detail by constructing a disconnectivity graph and by examining the organization of pathways on the surface. The results clearly reveal the frustration exhibited by this system and explain why it does not fold efficiently to the global potential energy minimum. In contrast, when the frustration is removed by constructing a “Gō-type”. model, the resulting graph exhibits the characteristics expected of a folding funnel.
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A 1999 study studied this question.
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