Four cyclic peptides of the type cyclo (Pro‐Gly)n were synthesized and characterized. The peptides are cyclo (L‐Pro‐Gly)2, cyclo (L‐Pro‐Gly)3, cyclo (L‐Pro‐Gly)4, and cyclo (D‐Pro‐Gly‐L‐Pro‐Gly). Aspects of the cyclization reactions leading to these peptides are discussed, particularly with respect to the choice of sequence of linear precursor peptides and effects of elevated temperatures. The cyclic octapeptide, cyclo (L‐Pro‐Gly)4, was isolated as a crystalline complex with sodium thiocyanate. Experimental details of the syntheses are provided.
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Deber et al. (1974) studied this question.
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