The Clinical Manifestations of Nicotinic Acid and Riboflavin Deficiency (Pellagra)

Article1 March 1941THE CLINICAL MANIFESTATIONS OF NICOTINIC ACID AND RIBOFLAVIN DEFICIENCY (PELLAGRA)V. P. SYDENSTRICKER, M.D., F.A.C.P.V. P. SYDENSTRICKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-9-1499 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe genesis of spontaneous deficiency disease in human beings is such that it is quite unlikely that an uncomplicated avitaminosis should occur. This is particularly the case in deficiencies of the B group of vitamins. These substances commonly occur together in their natural sources and have closely related functions in essential metabolic processes so that any circumstance which causes inadequate intake, poor utilization or rapid depletion of one of these vitamins is almost certain to affect the whole group. 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