Key result
Analysis of 15 Trypanosoma cruzi isolates revealed large differences in restriction fragment lengths of SAPA and antigen 30 genes, explained by variations in the number of tandem repeat units.
Population
15 Trypanosoma cruzi isolates and clones collected in distant geographical regions
Design
Preclinical
Authors
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T. cruzi antigen heterogeneity may affect Chagas diagnostics; leaves open implications for vaccine design and immune evasion studies.
Differences in the number of repeat units in T. cruzi antigen genes explain the large size heterogeneity in otherwise homologous antigens.
Macina et al. (1989) studied Chagas' disease (Trypanosoma cruzi) (n=15). Genetic analysis of SAPA and antigen 30 genes was evaluated on Variations in the number of repeat units in homologous genes. Analysis of 15 Trypanosoma cruzi isolates revealed large differences in restriction fragment lengths of SAPA and antigen 30 genes, explained by variations in the number of tandem repeat units.
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