The syntheses of unnatural amino acids, 1-amino-3-[2-(7-(2-hydroxyethyl)-1,7-dicarba- closo -dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid ( 2 ) and its nido analog 1-amino-3-[2-(7-(2-hydroxyethyl)-1,7-dicarba- nido -dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid ( 3 ) were achieved. The key steps in the syntheses of 2 and 3 involved the sequential dialkylation of m -carborane and an intramolecular ethoxide ion mediated cage degradation process.
No takes yet. Share an insight, caveat, or question.
Srivastava et al. (1997) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: