Potential anticonvulsants. VII. Synthesis of 5′‐methylspiro[3H‐indole‐3,2′‐thiazolidine]‐2,4′(1H)‐diones

This is the authors' abstract. We don't add key points for this paper.

The title compounds have been prepared, by the cyclocondensation of thiolactic acid with isatin‐3‐imines. 5′‐Methyl‐3′‐phenyl‐spiro[3H‐indole‐3,2′‐thiazolidine]‐2,4′(1H)‐dione has been subjected to the Mannich condensation to give 1‐substituted derivatives. With one exception, all of the products were inactive in an anticonvulsant screen.