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To test a proposal that stereochemistry can be used rationally to control the binding properties of ionophores, a new podand (3) has been prepared and studied. Unlike the previously prepared stereoisomeric podand 2 which has substitution and stereochemistry which enforces a single tetradentate binding conformation, 3 has been designed to avoid conformations in which all four oxygens can simultaneously coordinate with an ion.
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Erickson et al. (1990) studied this question.
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