Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning

Luigi Tritapepe; Guido Macchiarelli; Monica Rocco; Francesco Scopinaro; Orazio Schillaci; Eugenio Martuscelli; Pietro M. Motta

doi:10.1097/00003246-199804000-00034

April 1, 1998Critical Care Medicine

Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning

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Key Points

Investigate human myocardial ultrastructural changes and functional impairment associated with reversible cardiac failure after acute carbon monoxide poisoning.
Evaluated a 25-year-old woman presenting with cardiac failure secondary to acute carbon monoxide poisoning.
Administered hyperbaric oxygen and intensive care treatment across a 10-day hospitalization.
Assessed cardiac status using 99mTc-sestaMIBI scintigraphy, coronary angiography, and electron microscopy of left ventricular endomyocardial biopsies.
Scintigraphy revealed an uptake defect in the left anterior descending artery territory, alongside anterior wall and septal hypokinesis despite completely normal coronary angiograms.
Electron microscopy demonstrated myocyte alterations characterized by abnormal glycogen accumulation and swollen mitochondria, indicating defective energy substrate utilization.
Cardiac dysfunction resolved fully with medical management and hyperbaric therapy, enabling clinical discharge on day 10.

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Implication

Case report demonstrates myocardial stunning and mitochondrial swelling in a patient with acute carbon monoxide poisoning, suggesting impaired cellular energy utilization.

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Tritapepe et al. (1998) studied this question.

synapsesocial.com/papers/6a9e0aa54bbd51f2272cb26b https://doi.org/10.1097/00003246-199804000-00034

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Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning

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Cite This Study

Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning

Key Points

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Implication

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Cite This Study

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