Among the variety of transducer concepts proposed for label‐free detection of biomolecules, the semiconductor field‐effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label‐free, fast and real‐time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point‐of‐care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label‐free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody‐antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
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Poghossian et al. (2014) studied this question.
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