Three dispersion amalgams were tested in vitro. Spherical-D and Dialloy showed very similar effects on the cells as did the Spherical and fine cut amalgams. The other disperison amalgam, Dispersalloy, had intense and persistent cytotoxicity even 24 hours after trituration. Difference of the results was presumed to result from different alloy composition.
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Nakamura et al. (1979) studied this question.
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