Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.

A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45. The producing organism was subsequently determined to be a new strain and named Streptomyces bottropensis DO-45. The antibiotics are active against Gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388.