Key result
A 291-nucleotide region of the bovine coronavirus genome functions as a packaging signal and is sufficient to package noncoronavirus RNA into both BCV and MHV virions.
Population
Bovine coronavirus (BCV) and mouse hepatitis coronavirus (MHV) virions / RNA transcripts
Design
Preclinical
Authors
Loading...
BCV packaging signal functions across coronaviruses in cell culture; leaves open utility for vector or antiviral design.
The study identifies the first bovine coronavirus packaging signal, demonstrating sequence and functional conservation with mouse hepatitis coronavirus.
Cologna et al. (2000) studied Bovine Coronavirus (in vitro). Bovine coronavirus packaging signal clone vs. Control constructs (CAT, BN3'-CAT) was evaluated on Packaging of RNA transcripts into extracellular virions. A 291-nucleotide region of the bovine coronavirus genome functions as a packaging signal and is sufficient to package noncoronavirus RNA into both BCV and MHV virions.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: