The Efficacy of Dexmedetomidine in Patients with Noninvasive Ventilation: A Preliminary Study

In Brief BACKGROUND: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV. METHODS: This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation. RESULTS: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 ± 0.94 and −1.23 ± 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened. CONCLUSION: This study shows that dexmedetomidine is an effective sedative drug for patients with NIV. IMPLICATIONS: Dexmedetomidine is an effective sedative drug for patients in whom noninvasive ventilation is difficult because of agitation.