Key result
Patients with heart disease frequently had normal or lower central volume indices compared to the 0.590 liters average in normal subjects, except for cor pulmonale patients who had higher volumes.
Why the study?
Does the dye dilution curve method reveal differences in central volume between normal subjects and patients with cardiovascular disorders?
Observational
Does the dye dilution curve method reveal differences in central volume between normal subjects and patients with cardiovascular disorders?
Dye dilution curves can be used to estimate central volume, which is elevated in cor pulmonale patients with high output but typically normal or reduced in other heart diseases.
Questions routine assumptions of expanded central volume in heart disease; leaves open etiology-specific targets for prospective trials.
Dye dilution curves determined by the method of Hamilton have been obtained from a series of normal subjects and from a group of patients with various types of cardiovascular disorders. Cardiac indices calculated from these curves revealed expected values. Central volume, believed to be an index of pulmonary blood volume, was calculated from the slopes of the down strokes of the curves. Central volume indices in normal subjects averaged 0.590 liters. Central volume in patients with heart disease was frequently normal or less than normal. Only cor pulmonale patients with high output had central volumes significantly greater than normal.
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Kattus et al. (1955) conducted an observational in Cardiovascular disorders. Cardiovascular disorders vs. Normal subjects was evaluated on Central volume indices. Patients with heart disease frequently had normal or lower central volume indices compared to the 0.590 liters average in normal subjects, except for cor pulmonale patients who had higher volumes.
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