Answers are grounded in this paper and cite their sources.
The synthesis of hippuric acid from benaoic acid and glycine resembles in several respects the synthesis of a peptide bond. A CONH group is formed, it is a to a carboxyl group, and the free energy of its formation is of the same order of magnitude. The synthesis was demonstrated in liver and kidney slices of a number of animals; it is inhibited by 0.001 M KCN, which is in accord with the view that the necessary free energy is derived from an oxidation.(1)
No takes yet. Share an insight, caveat, or question.
Borsook et al. (1947) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: