Two hundred and twenty‐three infants and children with rectal temperatures greater than 101° due to diseases commonly encountered in pediatric practice, were given indomethacin suspension, indomethacin placebo or acetaminophen elixir in a random coded manner according to prescribed dosage schedules. The mean temperature reduction in those groups treated with indomethacin and acetaminophen was statistically significantly better than placebo, and a significant difference in temperature reduction was found between indomethacin and acetaminophen with indomethacin being superior.
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Earl T. Brewer (1968) studied this question.
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