DNA jigsaw pieces enable the preparation of predesigned unidirectional DNA assemblies by using a programmed-assembly system. In their Full Paper on page 5362 ff., M. Endo, H. Sugiyama et al. describe how DNA jigsaw piece monomers were assembled preferentially through defined connections in a “key-and-lock” fashion after slow annealing. Additionally, DNA jigsaw pieces with alphabet letters were arranged to display three-, four-, and five-letter words.
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Endo et al. (2010) studied this question.