Key result
Coadministration of apelin with T4 effectively diminished mean TSH level, LDL/HDL ratio, and atherogenic index in PTU-induced hypothyroid rats compared with the hypothyroid group.
Why the study?
Hyperlipidemia is a common metabolic disorder that may arise in hypothyroidism, and apelin is involved in energy storage and metabolism.
Does apelin alone or combined with T4 improve TSH levels and lipid profiles in PTU-induced hypothyroid rats?
Does apelin alone or combined with T4 improve TSH levels and lipid profiles in PTU-induced hypothyroid rats?
Coadministration of apelin with T4 improves TSH levels and lipid profiles in a rat model of hypothyroidism.
May improve TSH and lipids when added to T4 in rat hypothyroidism; hypothesis-generating and requires human trials before any clinical consideration.
Hyperlipidemia is a common metabolic disorder in the general population, which may arise in hypothyroidism. Apelin is an endogenous ligand that acts as an adiponectin, and is involved in energy storage and metabolism. This study evaluated the effects of apelin administration per se or in combination with T4 on the serum level of thyroid-stimulating hormone (TSH), body weight, and lipid profile, along with the serum level of apelin, and its mRNA expression in heart, in 6-propyl-2-thiouracil (PTU)-induced hypothyroid rats. Male Wistar rats were assigned to five different groups: control, H (hypothyroid), H+A, H+T, and H+A+T. All groups except the control one received PTU (0.05%) in the drinking water for 6 weeks. In addition to PTU, the H+A, H+T, and H+A+T groups received apelin (200 μg/kg/day, i.p.), l-thyroxin (T4) (20 μg/kg/day, via gavage tube), and apelin+T4 during the last 14 days of the trial, respectively. A combined application of T4 and apelin in the H+A+T group effectively diminished mean TSH level, low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol ratio, and atherogenic index in these animals when compared with these values for the H group. Coadministration of apelin with T4 may offer valuable therapeutic benefits, specifically lowering blood plasma TSH, lipid disorder, and atherosclerosis biomarkers in PTU-induced hypothyroid rats.
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Badavi et al. (2021) studied PTU-induced hypothyroidism. Apelin and T4 vs. Hypothyroid group (H) was evaluated on mean TSH level, LDL/HDL ratio, and atherogenic index. Coadministration of apelin with T4 effectively diminished mean TSH level, LDL/HDL ratio, and atherogenic index in PTU-induced hypothyroid rats compared with the hypothyroid group.
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