Gliotoxin ( 1 ), a fungal metabolite, inhibited acetolactate synthase (ALS), one of the targets of commercial herbicides. The inhibitory effect of gliotoxin was more potent against yeast ALS than against tobacco cells. The ALS inhibitory activity of gliotoxin was considered to be associated with the 1,4-dione moiety. p -Benzoquinones and naphthoquinones, which have 1,4-dione moiety, also showed ALS inhibition. 2-Methyl-substituted derivatives were especially potent inhibitors of yeast ALS.
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Haraguchi et al. (1997) studied this question.
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