Key result
Increasing age was significantly associated with shorter distal latency, higher integrated relaxation pressure, and higher distal contractile integral during high-resolution esophageal manometry.
Why the study?
Does age affect the key parameters of the Chicago classification in high-resolution esophageal manometry among asymptomatic healthy individuals?
Cross-Sectional (n=54)
Does age affect the key parameters of the Chicago classification in high-resolution esophageal manometry among asymptomatic healthy individuals?
Answers are grounded in this paper and cite their sources.
Age significantly affects key parameters of the Chicago classification in esophageal manometry, suggesting that age-adjusted normal values may be necessary.
BACKGROUND: High-resolution manometry using the Chicago classification, which utilizes parameters including integrated relaxation pressure (IRP), distal contractile integral (DCI), and contractile front velocity (CFV), shows better diagnostic ability than previous conventional criteria. However, the current normal cut-off values for the Chicago classification are based on individuals aged 19-48 years and do not include older people. Here, we aimed to assess the normal values for the Chicago classification in individuals aged 20-67 years and compare the parameters across age groups. METHODS: Fifty-four asymptomatic healthy individuals (27 male and 27 female; age range. 20-67 years) were prospectively enrolled. To evaluate the effect of age and sex on manometric profiles, we attempted to enroll equal numbers of male and female subjects for each decade. Manometry was performed in both the supine and sitting positions. KEY RESULTS: The distal latency (DL) was significantly shorter with increasing age in both measurement positions. Furthermore, IRP was significantly higher with increasing age in both positions. Spearman's ranked correlation coefficient analysis indicated that DCI and IRP in both positions were positively correlated with age. CONCLUSIONS & INFERENCES: Age affects the key parameters currently used in the Chicago classification, including IRP, DCI, and DL. Larger prospective studies with older subjects are needed to determine the age-related normal values for the Chicago classification system.
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Jung et al. (2014) conducted a cross-sectional in asymptomatic healthy individuals (n=54). Age was evaluated on Chicago classification parameters including integrated relaxation pressure (IRP), distal contractile integral (DCI), and distal latency (DL). Increasing age was significantly associated with shorter distal latency, higher integrated relaxation pressure, and higher distal contractile integral during high-resolution esophageal manometry.
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