Key result
Electrical stimulation of the myenteric plexus and hypogastric nerve induced a frequency-dependent increase in nitric oxide release, observed at nerve terminals, axons, and somas.
Population
Myenteric plexus and hypogastric nerve tissues
Comparison
Electrical stimulation vs Inhibition of NO synthase or tetrodotoxin
Design
Preclinical
Authors
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Animal data suggest non-synaptic nitric oxide signaling in autonomic nerves; leaves open relevance to human cardiovascular regulation.
Nitric oxide is released from the whole nerve cell (terminals, axon, and soma), suggesting it functions as a mechanism of both synaptic and non-synaptic communication.
Wiklund et al. (1997) studied this question. Electrical stimulation vs. Inhibition of NO synthase or tetrodotoxin was evaluated on Photon counts (visualisation of NO). Electrical stimulation of the myenteric plexus and hypogastric nerve induced a frequency-dependent increase in nitric oxide release, observed at nerve terminals, axons, and somas.
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