Unsymmetrical is beautiful: Enzymatic desymmetrization offers a mild route to chiral synthons with, in principle, 100 % yield and absolute optical purity. The technique has been applied to bicyclic β-diketones for the first time, through a novel enzymatic retro-Claisen reaction, to yield chiral cyclic keto acids in up to 91 % yield and 94 % ee (see scheme, step a).
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Grogan et al. (2001) studied this question.
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