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Photosensitized HeLa cells receiving high-intensity pulsed laser irradiation exhibited pores on the membrane surface. We attempted to deliver FITC-labeled dextran (71.6 kDa) into the cell cytoplasm. The ratio of FITC-positive cells in photodynamic-treated HeLa cells was significantly higher than that of non-treated HeLa cells, with no loss in cell viability.
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Miyamoto et al. (2004) studied this question.
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