Novel chelate ring-opening occurs when cytotoxic bis(aminoethylphosphanyl)platinum(II) binds rapidly to the N3 atom of the DNA base thymine (T) and RNA base uracil (U) at pH 7 in the presence of chloride ions (depicted on the right). This is in contrast to cisplatin, which shows little binding to thymine or uracil under similar conditions, and thus opens the possibility for base-specific attack on DNA and RNA.
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Margiotta et al. (1997) studied this question.
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