Key result
Levorphanol inhibits RNA synthesis in Escherichia coli by 80-90% at a concentration of approximately 1x10^-3 M, occurring before the complete cessation of bacterial growth.
Population
Escherichia coli
Design
Preclinical
Authors
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Should not change clinical practice; leaves open mechanistic studies of levorphanol in bacteria.
Effect estimate: 80-90% reduction
Levorphanol inhibits RNA synthesis in Escherichia coli.
Simon et al. (1964) studied this question. Levorphanol vs. Control (untreated or chloramphenicol-treated E. coli) was evaluated on RNA synthesis (measured by P32 or C14-uracil incorporation into RNA nucleotides) (80-90% reduction). Levorphanol inhibits RNA synthesis in Escherichia coli by 80-90% at a concentration of approximately 1x10^-3 M, occurring before the complete cessation of bacterial growth.
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