Synthesis of Macrocyclic Lactones by Ring Enlargement Reaction Treatment of 3‐(1‐nitro‐2‐oxocyclohexyl)propanal (1) prepared by Michael addition of 2‐nitrocyclohexanon and acrylaldehyde with methyltri (2‐propoxy)tita‐nium yielded a mixture of 2 and 3 which was converted into 6‐nitro‐9‐decanolide (4).
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Kostova et al. (1982) studied this question.
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