Key result
Immunohistochemical analysis of cardiac myxomas showed positive staining for fibronectin, Factor VIII, and actin, suggesting the tumors arise from multipotential mesenchymal cells.
Case Report (n=5)
Immunohistochemical profiling suggests cardiac myxomas arise from multipotential mesenchymal cells differentiating into vascular and immature smooth muscle cells.
Does not alter myxoma management; leaves open mesenchymal origin hypothesis pending validation studies.
Clinicopathological studies, especially morphological and immunohistochemical observations, were performed on five cases of cardiac myxoma. Tumor cells were arranged singly, in cords and showed differentiated vascular structures. Immunohistochemically, fibronectin was localized in superficial covering cells, endothelial cells and in the pericellular regions of tumor cells. Factor VIII-related antigen was proved in the endothelial cells of blood vessels in the myxomas. Actin was detected in all tumor cells including superficial covering cells and endothelial cells. However S-100, keratin and myoglobin were negative in the myxoma tumor cells. These immunohistochemical findings may suggest that cardiac myxoma is composed of vascular and immature smooth muscle cells arising from multipotential mesenchymal cells.
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Kimura et al. (1986) conducted a case report in Cardiac myxoma (n=5). Immunohistochemical staining was evaluated on Immunohistochemical localization of cellular markers. Immunohistochemical analysis of cardiac myxomas showed positive staining for fibronectin, Factor VIII, and actin, suggesting the tumors arise from multipotential mesenchymal cells.
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