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February 1, 1998Journal of Natural Products

Fomitellic Acids, Triterpenoid Inhibitors of Eukaryotic DNA Polymerases from a Basidiomycete, Fomitella fraxinea

Nobukazu Tanaka Akitoshi Kitamura Yoshiyuki Mizushina Fumio Sugawara Kengo Sakaguchi

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Abstract

Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.

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Tanaka et al. (1998) studied this question.

synapsesocial.com/papers/6a9e3726e056b05edee9850c https://doi.org/10.1021/np970127a

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