Key result
The serum ratio of hFABP to myoglobin after hemodialysis significantly correlated with cardiac markers and echocardiographic indices, unlike hFABP or myoglobin alone.
Why the study?
Does the serum ratio of hFABP to myoglobin (F/M) correlate with markers of cardiac damage and volume overload in hemodialysis patients?
Observational (n=21)
Does the serum ratio of hFABP to myoglobin (F/M) correlate with markers of cardiac damage and volume overload in hemodialysis patients?
Answers are grounded in this paper and cite their sources.
The post-hemodialysis serum ratio of hFABP to myoglobin may serve as a useful marker for estimating cardiac damage and volume overload in patients with renal dysfunction.
BACKGROUND: The concentration of heart-type fatty acid-binding protein (hFABP), a promising novel marker for detection of acute or persistent myocardial damage, is significantly influenced by renal clearance and thus has limitations to its usefulness in patients with renal dysfunction. We evaluated whether the serum ratio of hFABP to myoglobin (F/M) might be a useful marker for assessing cardiac damage in hemodialysis patients. METHODS: Serum hFABP and myoglobin were measured, and the value of F/M was calculated in 21 hemodialysis patients. Cardiac markers (cardiac troponin T [cTnT], atrial natriuretic peptide [ANP], and brain natriuretic peptide [BNP]) and echocardiographic indices (left ventricular end-diastolic dimension [LVDd], left ventricular mass index [LVMI], and inferior vena cava [IVC] dimension) were examined and compared with hFABP, myoglobin, and F/M ratios. RESULTS: Serum hFABP and myoglobin levels were significantly elevated in hemodialysis patients and reduced by 30-40% during hemodialysis. The value of F/M after hemodialysis, but not the concentration of hFABP or myoglobin, had significant linear correlations with ANP, BNP, cTnT, LVDd, LVMI, and IVC. CONCLUSION: The value of F/M after hemodialysis, but not the concentration of hFABP itself, might be a newly useful marker for estimation of cardiac damage and volume overload in hemodialysis patients.
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Furuhashi et al. (2003) conducted an observational in Hemodialysis (n=21). Serum ratio of heart-type fatty acid-binding protein to myoglobin (F/M) vs. hFABP or myoglobin concentration alone was evaluated on Correlation with cardiac markers (ANP, BNP, cTnT) and echocardiographic indices (LVDd, LVMI, IVC). The serum ratio of hFABP to myoglobin after hemodialysis significantly correlated with cardiac markers and echocardiographic indices, unlike hFABP or myoglobin alone.
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