Technical review reveals advanced fiber-optic nanobiophotonics for subwavelength bioimaging and sensing at cellular levels, suggesting transformative potential for minimally invasive diagnostics.
The main goal of this study is to develop novel fiber-optic-based nanobiophotonics techniques for noninvasive imaging and biosensing optical properties of cellular and tissue samples beyond the diffraction barrier in the subwavelength nanoscale range. The work covers fundamental principles, recent developments, and trends in advanced nanobiophotonics techniques exploited for either minimally invasive diagnostics and imaging in biomedicine at cellular/intracellular level or development of nanosensors and nanostructured materials. Somerecently developed advanced ultrahigh-resolution nanotechnologies such as confocal nanoscopy and fiber-optic-based nanosensors, will also be discussed. These technologies allow one to break the theoretical optical diffraction barrier and to work in the subwavelength nanoscale range
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Ilko K. Ilev (2006) studied this question.
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