Synthesis of nucleosides and related compounds. Part 21. Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-1-cyclopropyl)-9H-adenine (a lower methylene homolog of carbocyclic oxetanocin) and related compounds.

To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2, c-3-dihydroxymethyl-r-1-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.