Key result
Complement-receptor lymphocytes were shown to be of extrathymic, bone marrow origin in thymectomized, irradiated, and marrow-grafted mice.
Complement-receptor lymphocytes are demonstrated to be of extrathymic, bone marrow origin in a mouse model.
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Limited to murine models; leaves open human translation of extrathymic bone marrow origins.
Substantial regeneration of complement‐receptor lymphocytes (CRL) took place in lymph nodes of adult thymectomized whole‐body X‐irradiated mice reconstituted with semi‐allogeneic (F1) bone marrow. In the presence of complement, alloantisera directed against the transplanted bone marrow killed more than 95% of the lymphoid cells of such chimeras. Moreover, lymph node cell suspensions and lymphoid tissue sections of neonatally thymectomized or adult thymectomized, irradiated and marrow‐grafted mice contained an increased proportion of CRL. The results concur to establish proof that CRL are of extrathymic, bone marrow origin.
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Dukor et al. (1971) studied this question. Bone marrow transplantation was evaluated on Origin of complement-receptor lymphocytes (CRL). Complement-receptor lymphocytes were shown to be of extrathymic, bone marrow origin in thymectomized, irradiated, and marrow-grafted mice.
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