THE PARTICIPATION OF THE HYPOPHYSIS in a causative or sustaining role in any form of clinical or experimental hypertension is in dispute (1). It is generally held that the hypophysis plays no direct part in the production of expert mental hypertension of the Goldblatt type (2–7). There is evidence, however, that the hypophysis may contribute to conditions favoring the existence of a hypertension by its effects upon other endocrine glands such as the adrenal cortex, or upon the responsiveness of the blood vessel musculature to pressor substances derived from ischaemic kidneys. Animals which are otherwise normal may show lowered blood pressures after hypophysectomy (2, 8, 9). Page and Sweet (2) and Page (8) have shown that hypophysectomy in dogs with experimental renal hypertension may cause definite decline in blood pressure. However, hypophysectomy will not always prevent the onset of a hypertension when the renal arteries are compressed subsequent to the hypophysectomy (2, 10).
No takes yet. Share an insight, caveat, or question.
Sattler et al. (1941) studied this question.