Gamma-glutamyl transferase (GGT) is a membrane-bound enzyme catabolising reduced glutathione to cysteine and glycine in Meister’s γ -glutamyl cycle ( Orlowski and Meister, 1970 ). This delivers cysteine for intracellular synthesis of glutathione, the major thiol anti-oxidant. Elevated serum levels of GGT are markers of oxidative stress, resulting from factors including alcohol, heavy metals, cardiovascular disease and diabetes.
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Ian S. Fentiman (2012) studied this question.
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