Nanomechanical Properties of Active Nanofibrous Implants After In Vivo Bone Regeneration

With the aging of the population and a correlated increase in the incidence of osteoarticular damage, great attention is focused on regenerative nanomedicine solutions to restore durable articular function and comfort. A durable cartilage repair is not effective without regeneration of an intact subchondral bed along with the surface chondral regeneration. Our expected outcomes are the development of clinical applications in the field of tissue engineering and nanomedicine, and more particularly in bone-cartilage unit regeneration. Here we report for the first time the nanomechanical analysis of the retrieved active implant after subchondral bone regeneration in vivo, which is much more efficient and long lasting solution to osteochondral defects than the existing ones. We believe that our results make a significant contribution to the area of regenerative nanomedicine. The concepts discovered here may serve to design sophisticated implants for placement into a broad variety of tissues.